DUSP1 promotes pancreatic cancer cell proliferation and invasion by upregulating nephronectin expression

Abstract Objectives To explore the role of dual-specific phosphatase 1 (DUSP1) in proliferation, migration and invasion pancreatic cancer (PC). Methods TCGA GTEx databases were used to investigate relationship between DUSP1 expression prognosis PC patients. Expression efficiency was validated by qPCR western blotting. The proliferation SW1990 PANC-1 cells with overexpression or knockout detected EdU assays. migratory invasive abilities wound healing transwell Results highly expressed associated poor Overexpression promoted regulating nephronectin (NPNT), whereas exhibited opposite effects. NPNT positively correlated DUSP1, overall survival patients high levels shorter. Conclusions upregulating NPNT, suggesting may be a potential target for treatment.